Cardiopulmonary Impact of Particulate Air Pollution in High-Risk Populations: JACC State-of-the-Art Review

Jonathan D Newman; Deepak L Bhatt; Sanjay Rajagopalan; John R Balmes; Michael Brauer; Patrick N Breysse; Alison G M Brown; Mercedes R Carnethon; Wayne E Cascio; Gwen W Collman; Lawrence J Fine; Nadia N Hansel; Adrian Hernandez; Judith S Hochman; Michael Jerrett; Bonnie R Joubert; Joel D Kaufman; Ali O Malik; George A Mensah; David E Newby; Jennifer L Peel; Jeffrey Siegel; David Siscovick; Betsy L Thompson; Junfeng Zhang; Robert D Brook

doi:10.1016/j.jacc.2020.10.020

Cardiopulmonary Impact of Particulate Air Pollution in High-Risk Populations: JACC State-of-the-Art Review

J Am Coll Cardiol. 2020 Dec 15;76(24):2878-2894. doi: 10.1016/j.jacc.2020.10.020.

Authors

Jonathan D Newman¹, Deepak L Bhatt², Sanjay Rajagopalan³, John R Balmes⁴, Michael Brauer⁵, Patrick N Breysse⁶, Alison G M Brown⁷, Mercedes R Carnethon⁸, Wayne E Cascio⁹, Gwen W Collman¹⁰, Lawrence J Fine⁷, Nadia N Hansel¹¹, Adrian Hernandez¹², Judith S Hochman¹³, Michael Jerrett¹⁴, Bonnie R Joubert¹⁵, Joel D Kaufman¹⁶, Ali O Malik¹⁷, George A Mensah¹⁸, David E Newby¹⁹, Jennifer L Peel²⁰, Jeffrey Siegel²¹, David Siscovick²², Betsy L Thompson²³, Junfeng Zhang²⁴, Robert D Brook²⁵

Affiliations

¹ Division of Cardiology and the Center for the Prevention of Cardiovascular Disease, New York University Grossman School of Medicine, New York, New York, USA. Electronic address: Jonathan.Newman@nyumc.org.
² Brigham and Women's Hospital Heart and Vascular Center and Harvard Medical School, Boston, Massachusetts, USA. Electronic address: https://twitter.com/DLBhattMD.
³ Harrington Heart and Vascular Institute, University Hospitals, Case Western Reserve University, Cleveland, Ohio, USA.
⁴ Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Department of Medicine, University of California, San Francisco, California, USA.
⁵ School of Population and Public Health, The University of British Columbia, Vancouver, British Columbia, Canada.
⁶ National Center for Environmental Health/Agency for Toxic Substances and Disease Registry, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
⁷ Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Washington, DC, USA.
⁸ Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
⁹ Center for Public Health and Environmental Assessment, U.S. Environmental Protection Agency, Durham, North Carolina, USA.
¹⁰ National Institute of Environmental Health Sciences, Durham, North Carolina, USA.
¹¹ Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
¹² Clinical Research, Duke University School of Medicine, Durham, North Carolina, USA.
¹³ New York University Grossman School of Medicine, New York, New York, USA.
¹⁴ Fielding School of Public Health, University of California, Los Angeles, California, USA.
¹⁵ Population Health Branch, Division of Extramural Research and Training, National Institute of Environmental Health Sciences, Durham, North Carolina, USA.
¹⁶ Departments of Environmental & Occupational Health Sciences, Medicine, and Epidemiology, University of Washington, Seattle, Washington, USA.
¹⁷ Saint Luke's Mid America Heart Institute, Kansas City, Missouri, USA.
¹⁸ Center for Translation Research and Implementation Science, National Heart, Lung, and Blood Institute, Washington, DC, USA.
¹⁹ British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom.
²⁰ Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado, USA.
²¹ Department of Civil and Mineral Engineering, and the Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
²² Division of Research, Evaluation, and Policy, The New York Academy of Medicine, New York, New York, USA.
²³ Division for Heart Disease and Stroke Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
²⁴ Nicholas School of the Environment & Duke Global Health Institute, Duke University, Durham, North Carolina, USA.
²⁵ Division of Cardiovascular Diseases, Wayne State University, Detroit, Michigan, USA.

Abstract

Fine particulate air pollution <2.5 μm in diameter (PM_2.5) is a major environmental threat to global public health. Multiple national and international medical and governmental organizations have recognized PM_2.5 as a risk factor for cardiopulmonary diseases. A growing body of evidence indicates that several personal-level approaches that reduce exposures to PM_2.5 can lead to improvements in health endpoints. Novel and forward-thinking strategies including randomized clinical trials are important to validate key aspects (e.g., feasibility, efficacy, health benefits, risks, burden, costs) of the various protective interventions, in particular among real-world susceptible and vulnerable populations. This paper summarizes the discussions and conclusions from an expert workshop, Reducing the Cardiopulmonary Impact of Particulate Matter Air Pollution in High Risk Populations, held on May 29 to 30, 2019, and convened by the National Institutes of Health, the U.S. Environmental Protection Agency, and the U.S. Centers for Disease Control and Prevention.

Keywords: cardiopulmonary disease; cardiovascular disease; fine particulate air pollution; portable air cleaner; randomized clinical trials.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Air Pollution / adverse effects*
Clinical Trials as Topic
Education
Heart Diseases / etiology
Heart Diseases / prevention & control*
Humans
Lung Diseases / etiology
Lung Diseases / prevention & control*
Particulate Matter / adverse effects*

Substances

Particulate Matter

Abstract

Publication types

MeSH terms

Substances

Grants and funding