Growth differentiation factor-15 levels in the blood around the pulmonary artery is associated with hospitalization for heart failure in patients with pulmonary arterial hypertension

Wei-Ting Chang; Jhih-Yuan Shih; Yu-Wen Lin; Zhih-Cherng Chen; Jun-Neng Roan; Chih-Hsin Hsu

doi:10.1177/2045894020962948

Growth differentiation factor-15 levels in the blood around the pulmonary artery is associated with hospitalization for heart failure in patients with pulmonary arterial hypertension

Pulm Circ. 2020 Nov 20;10(4):2045894020962948. doi: 10.1177/2045894020962948. eCollection 2020 Oct-Dec.

Authors

Wei-Ting Chang^{1

2

3}, Jhih-Yuan Shih², Yu-Wen Lin², Zhih-Cherng Chen², Jun-Neng Roan^{4

5

6}, Chih-Hsin Hsu^{7

8

9}

Affiliations

¹ Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan.
² Division of Cardiology, Department of Internal Medicine, Chi-Mei Medical Center, Tainan.
³ Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan.
⁴ Medical Device Innovation Center, National Cheng Kung University, Tainan.
⁵ Division of Cardiovascular Surgery, Department of Surgery, National Cheng Kung University Hospital, Tainan.
⁶ College of Medicine, National Cheng Kung University, Tainan.
⁷ Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
⁸ Department of Internal Medicine, National Cheng Kung University Hospital, Dou-Liou Branch, Yunlin, Taiwan.
⁹ Department of Respiratory Therapy, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

Abstract

Despite no significant differences of growth differentiation factor-15 expressions in peripheral, right atrial, and right ventricular blood, in the pulmonary arterial blood, there was a significantly high level of growth differentiation factor-15 in Group I pulmonary arterial hypertension patients subsequently developing heart failure. During right heart catheterization, collecting pulmonary blood samples is suggested to measure growth differentiation factor-15.

Keywords: growth differentiation factor-15 (GDF-15); heart failure hospitalization; intracardiac; pulmonary biomarkers.