[Gamma heavy chain disease associated with aggressive B lymphoma in the context of myelodysplastic syndrome]

Abstract

Introduction: Heavy chain disease is a rare entity characterized by the production of incomplete immunoglobulin heavy chain without associated light chain. It is a B-cell lymphoproliferation, categorized according to the immunoglobulin involved. It is often associated with lymphomas but also with autoimmune diseases.

Observation: We report the case of a 70-year-old patient who presented a gamma-type heavy chain disease, associated with a diffuse large B-cell lymphoma in the context of myelodysplastic syndrome.

Conclusion: This is the first case of diffuse large B-cell lymphoma associated gamma heavy chain disease described in the context of myelodysplastic syndrome.

Keywords: Heavy chain disease; Lymphoma; Lymphome; Maladie des chaînes Lourdes; Myelodysplasia; Myélodysplasie.