Synthesis of potentially new schiff bases of N-substituted-2-quinolonylacetohydrazides as anti-COVID-19 agents

Mohammed B Alshammari; Mohamed Ramadan; Ashraf A Aly; Essmat M El-Sheref; Md Afroz Bakht; Mahmoud A A Ibrahim; Ahmed M Shawky

doi:10.1016/j.molstruc.2020.129649

Synthesis of potentially new schiff bases of N-substituted-2-quinolonylacetohydrazides as anti-COVID-19 agents

J Mol Struct. 2021 Apr 15:1230:129649. doi: 10.1016/j.molstruc.2020.129649. Epub 2020 Nov 16.

Authors

Mohammed B Alshammari¹, Mohamed Ramadan², Ashraf A Aly³, Essmat M El-Sheref³, Md Afroz Bakht¹, Mahmoud A A Ibrahim³, Ahmed M Shawky⁴

Affiliations

¹ Chemistry Department, College of Sciences and Humanities, Prince Sattam bin Abdulaziz University, P.O. Box 83, Al-Kharij 11942, Saudi Arabia.
² Department of Organic Pharmacy, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Egypt.
³ Chemistry Department, Faculty of Science, Minia University, El-Minia 61519, Egypt.
⁴ Science and Technology Unit (STU), Umm Al-Qura University, Makkah 21955, Saudi Arabia.

Abstract

We report herein a new series of synthesized N-substituted-2-quinolonylacetohydrazides aiming to evaluate their activity towards SARS-CoV-2. The structures of the obtained products were fully confirmed by NMR, mass, IR spectra and elemental analysis as well. Molecular docking calculations showed that most of the tested compounds possessed good binding affinity to the SARS-CoV-2 main protease (M^pro) comparable toRemdesivir.

Keywords: Molecular docking; N-substituted-2-quinolonylacetohydrazides; Nmr; Quinolone; Remdesivir.