Association Between Preadmission Acid Suppressive Medication Exposure and Severity of Illness in Patients Hospitalized With COVID-19

B Joseph Elmunzer; Bethany J Wolf; James M Scheiman; William M Tierney; Jason R Taylor; North American Alliance for the Study of Digestive Manifestations of COVID-19

doi:10.1053/j.gastro.2020.11.007

Association Between Preadmission Acid Suppressive Medication Exposure and Severity of Illness in Patients Hospitalized With COVID-19

Gastroenterology. 2021 Mar;160(4):1417-1422.e14. doi: 10.1053/j.gastro.2020.11.007. Epub 2020 Nov 12.

Authors

B Joseph Elmunzer¹, Bethany J Wolf², James M Scheiman³, William M Tierney⁴, Jason R Taylor⁵; North American Alliance for the Study of Digestive Manifestations of COVID-19

Collaborators

North American Alliance for the Study of Digestive Manifestations of COVID-19:
Ambreen A Merchant, Vaishali A Patel, Field F Willingham, Eric F Howard, Mary K West, Casey L Koza, Patrick S Yachimski, Emad Qayed, Rosemary Nustas, Ali Zakaria, Marc S Piper, Lujain Jaza, Nauzer Forbes, Millie Chau, Luis F Lara, Georgios I Papachristou, Uchechi Okafor, Darwin L Conwell, Michael L Volk, Evan Mosier, Mohamed Azab, Anish Patel, Liam G Hilson, Selena Zhou, James Buxbaum, Vladimir M Kushnir, Alexandria M Lenyo, Ian P Sloan, Thomas Hollander, Caroline G McLeod, Rebecca L Spitzer, Lauren Wakefield, Haley Nitchie, Collins O Ordiah, Don C Rockey, Teldon B Alford, Sunil Amin, Gabriela N Kuftinec, Amar R Deshpande, Dhiraj Yadav, Melissa Saul, Melanie Mays, Gulsum Anderson, Kelley Wood, Laura Mathews, Charlie Fox, Jennifer M Kolb, Sachin Wani, Swati Pawa, Rishi Pawa, Andrew Canakis, Christopher Huang, Laith H Jamil, Andrew M Aneese, V Mihajlo Gjeorgjievski, Zaid Imam, Fadi Odish, Ahmed I Edhi, Molly Orosey, Abhinav Tiwari, Soumil Patwardhan, Benita K Glamour, Zachary L Smith, Amy E Hosmer, Nancy Furey, Amitabh Chak, Katherine A Hanley, Jordan Wood, Rajesh N Keswani, Harsh K Patel, Janak N Shah, Emil Agarunov, Nicholas G Brown, Anish A Patel, Amrita Sethi, Evan L Fogel, Gail McNulty, Abdul Haseeb, Judy A Trieu, Rebekah E Dixon, Jeong Yun Yang, Christopher J DiMaio, Robin B Mendelsohn, Delia Calo, Olga C Aroniadis, Joseph F LaComb, Lilian Cruz, Olga Reykhart, Bryan G Sauer, Galina Diakova, Duyen T Dang, Cyrus R Piraka, Eric D Shah, Molly Caisse, Natalia H Zbib, John A Damianos, Heiko Pohl, Stephanie Mitchell, Michael S Bronze, Ashwinee Condon, Adrienne Lenhart, Raman Muthusamy, Kulwinder S Dua, Vikram S Kanagala, James Esteban, Ayesha Kamal, Marcia I Canto, Vikesh K Singh, Maria Ines Pinto-Sanchez, Joy M Hutchinson, Richard S Kwon, Sheryl J Korsnes, Akbar K Waljee, Weijing Tang, Yueyang Zhang, Ji Zhu, Harminder Singh, Zahra Solati, Nick Hajidiacos

Affiliations

¹ Division of Gastroenterology and Hepatology, Medical University of South Carolina, Charleston, South Carolina. Electronic address: elmunzer@musc.edu.
² Department of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina.
³ Division of Gastroenterology, University of Virginia Medical School, Charlottesville, Virginia.
⁴ Section of Digestive Diseases and Nutrition, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.
⁵ Division of Gastroenterology and Hepatology, Saint Louis University, St. Louis, Missouri.

No abstract available

Keywords: COVID-19; Histamine 2 Receptor Antagonists; Proton Pump Inhibitor; SARS-CoV-2.

MeSH terms

Adult
Aged
COVID-19 / complications*
COVID-19 / mortality
Female
Histamine H2 Antagonists / adverse effects*
Hospitalization
Humans
Male
Middle Aged
Proton Pump Inhibitors / adverse effects*
Retrospective Studies
SARS-CoV-2*
Severity of Illness Index

Substances

Histamine H2 Antagonists
Proton Pump Inhibitors

Grants and funding

P30 DK123704/DK/NIDDK NIH HHS/United States