A Photoregulated Racemase Mimic

Monochura Saha; Munshi Sahid Hossain; Subhajit Bandyopadhyay

doi:10.1002/anie.202012124

A Photoregulated Racemase Mimic

Angew Chem Int Ed Engl. 2021 Mar 1;60(10):5220-5224. doi: 10.1002/anie.202012124. Epub 2021 Jan 12.

Authors

Monochura Saha¹, Munshi Sahid Hossain¹, Subhajit Bandyopadhyay¹

Affiliation

¹ Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER) Kolkata, Mohanpur, Nadia, West Bengal, 741246, India.

PMID: 33180335
DOI: 10.1002/anie.202012124

Abstract

The racemase enzymes convert L-amino acids to their D-isomer. The reaction proceeds through a stepwise deprotonation-reprotonation mechanism that is assisted by a pyridoxal phosphate (PLP) coenzyme. This work reports a PLP-photoswitch-imidazole triad where the racemization reaction can be controlled by light by tweaking the distance between the basic residue and the reaction centre.

Keywords: azobenzene; biomimetic; photochemistry; photochromism; racemase.

Publication types

Research Support, Non-U.S. Gov't