A new chapter in the CD8 T reg story

Harvey Cantor; Hye-Jung Kim

doi:10.1084/jem.20201746

A new chapter in the CD8 T reg story

J Exp Med. 2021 Jan 4;218(1):e20201746. doi: 10.1084/jem.20201746.

Authors

Harvey Cantor^{1

2}, Hye-Jung Kim^{1

2}

Affiliations

¹ Department of Immunology, Harvard Medical School, Boston, MA.
² Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA.

Abstract

CD8+ T reg cells play an important role in the maintenance of self-tolerance and can inhibit the development of autoimmune disease. In this issue of JEM, Mishra et al. (https://doi.org/10.1084/jem.20200030) reveal that TGF-β signaling and an Eomes-dependent genetic program contribute to CD8 T reg cell differentiation and function.

Publication types

Comment

MeSH terms

CD8-Positive T-Lymphocytes*
Cell Differentiation
Immune Tolerance*
Self Tolerance