The RNA binding protein SRSF1 is a master switch of gene expression and regulation in the immune system

Cytokine Growth Factor Rev. 2021 Feb:57:19-26. doi: 10.1016/j.cytogfr.2020.10.008. Epub 2020 Nov 2.

Abstract

Serine/Arginine splicing factor 1 (SRSF1) is an RNA binding protein abundantly expressed in most tissues. The pleiotropic functions of SRSF1 exert multiple roles in gene expression by regulating major steps in transcription, processing, export through the nuclear pores and translation of nascent RNA transcripts. The aim of this review is to highlight recent findings in the functions of this protein and to describe its role in immune system development, functions and regulation.

Keywords: SLE; SR protein; Splicing; Transcription; Translation; mRNA; miRNA.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Gene Expression
  • Humans
  • Immune System*
  • RNA-Binding Proteins / genetics
  • Serine-Arginine Splicing Factors / genetics

Substances

  • RNA-Binding Proteins
  • SRSF1 protein, human
  • Serine-Arginine Splicing Factors