An outbreak of adenovirus D8 keratoconjunctivitis in Leicester, United Kingdom, from March to August 2019

J Med Virol. 2021 Jun;93(6):3969-3973. doi: 10.1002/jmv.26647. Epub 2020 Dec 17.

Abstract

We report a large epidemic (n = 126) of keratoconjunctivitis predominantly with two lineages of adenovirus (AdV) type D8 in patients seen in eye casualty between march and August 2019. Other AdV species identified by viral sequencing included B, C, and E. Despite various features of more severe eye disease being present, these were not significantly different between the different AdV species, with similar rates of pseudomembrane formation and keratitis observed in patients with AdV species B as for those with AdV species D.

Keywords: UK; adenovirus; community; incidence; keratoconjunctivitis; nosocomial; outbreak; transmission.

MeSH terms

  • Adenovirus Infections, Human / complications*
  • Adenovirus Infections, Human / epidemiology*
  • Adenoviruses, Human / classification
  • Adenoviruses, Human / genetics*
  • Adenoviruses, Human / pathogenicity
  • Adolescent
  • Adult
  • Cross Infection / epidemiology
  • Disease Outbreaks*
  • Eye / virology
  • Female
  • Humans
  • Keratoconjunctivitis / epidemiology*
  • Keratoconjunctivitis / virology*
  • Male
  • Middle Aged
  • United Kingdom / epidemiology
  • Young Adult