A Network Pharmacology Technique to Investigate the Synergistic Mechanisms of Salvia miltiorrhiza and Radix puerariae in Treatment of Cardio-Cerebral Vascular Diseases

Yang Ma; Wenjun Wang; Jiani Yang; Sha Zhang; Zhe Li; Fei Li; Shaojie Huang; Lu Lei; Kai Wang; Aidong Wen; Yi Ding

doi:10.1155/2020/6937186

A Network Pharmacology Technique to Investigate the Synergistic Mechanisms of Salvia miltiorrhiza and Radix puerariae in Treatment of Cardio-Cerebral Vascular Diseases

Evid Based Complement Alternat Med. 2020 Oct 5:2020:6937186. doi: 10.1155/2020/6937186. eCollection 2020.

Authors

Yang Ma^{1

2}, Wenjun Wang^{1

2}, Jiani Yang¹, Sha Zhang³, Zhe Li³, Fei Li¹, Shaojie Huang², Lu Lei¹, Kai Wang^{1

2}, Aidong Wen^{1

2}, Yi Ding^{1

2}

Affiliations

¹ College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, China.
² Department of Pharmacy, Xijing Hospital of the Fourth Military Medical University, Xi'an, China.
³ Department of Basic Medicine, Shaanxi University of Chinese Medicine, Xianyang, China.

Abstract

Objective: This study is aimed to analyze the active ingredients, drug targets, and related pathways in the combination of Salvia miltiorrhiza (SM) and Radix puerariae (RP) in the treatment of cardio-cerebral vascular diseases (CCVDs).

Method: The ingredients and targets of SM and RP were obtained from Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), and the disease targets were obtained from Therapeutic Target Database (TTD), National Center for Biotechnology Information (NCBI), and Online Mendelian Inheritance in Man (OMIM) Database. The synergistic mechanisms of the SM and RP were evaluated by gene ontology (GO) enrichment analyses and Kyoto encyclopedia of genes and genomes (KEGG) path enrichment analyses.

Result: A total of 61 active ingredients and 58 common targets were identified in this study. KEGG pathway enrichment analysis results showed that SM- and RP-regulated pathways were mainly inflammatory processes, immunosuppression, and cardiovascular systems. The component-target-pathway network indicated that SM and RP exert a synergistic mechanism for CCVDs through PTGS2 target in PI3k-Akt, TNF, and Jak-STAT signaling pathways.

Conclusion: In summary, this study clarified the synergistic mechanisms of SM and RP, which can provide a better understanding of effect in the treatment of CCVDs.