KPC-3-Producing Serratia marcescens Outbreak between Acute and Long-Term Care Facilities, Florida, USA

Emerg Infect Dis. 2020 Nov;26(11):2746-2750. doi: 10.3201/eid2611.202203.

Abstract

We describe an outbreak caused by Serratia marcescens carrying blaKPC-3 that was sourced to a long-term care facility in Florida, USA. Whole-genome sequencing and plasmid profiling showed involvement of 3 clonal lineages of S. marcescens and 2 blaKPC-3-carrying plasmids. Determining the resistance mechanism is critical for timely implementation of infection control measures.

Keywords: CPE; Florida; KPC; KPC-3; Klebsiella pneumoniae carbapenemase; Serratia marcescens; United States; antimicrobial resistance; bacteria; bacterial proteins; beta-lactamase; carbapenem-resistant Enterobacteriaceae; carbapenemase; disease outbreaks; infection control; infections; long-term care.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Bacterial Agents / pharmacology
  • Bacterial Proteins / genetics
  • Disease Outbreaks*
  • Female
  • Florida / epidemiology
  • Humans
  • Long-Term Care
  • Male
  • Middle Aged
  • Nursing Homes
  • Plasmids / genetics
  • Serratia Infections / epidemiology*
  • Serratia marcescens* / genetics
  • Young Adult
  • beta-Lactamases / genetics

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • beta-Lactamases