Antibody Therapy Goes to Insects: Monoclonal Antibodies Can Block Plasmodium Transmission to Mosquitoes

Camila H Coelho; Matthijs M Jore; Gaspar E Canepa; Carolina Barillas-Mury; Teun Bousema; Patrick E Duffy

doi:10.1016/j.pt.2020.08.009

Antibody Therapy Goes to Insects: Monoclonal Antibodies Can Block Plasmodium Transmission to Mosquitoes

Trends Parasitol. 2020 Nov;36(11):880-883. doi: 10.1016/j.pt.2020.08.009. Epub 2020 Oct 6.

Authors

Camila H Coelho¹, Matthijs M Jore², Gaspar E Canepa³, Carolina Barillas-Mury³, Teun Bousema⁴, Patrick E Duffy⁵

Affiliations

¹ Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. Electronic address: camila.coelho@nih.gov.
² Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands.
³ Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.
⁴ Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands; Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, UK.
⁵ Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. Electronic address: patrick.duffy@nih.gov.

PMID: 33036937
DOI: 10.1016/j.pt.2020.08.009

Abstract

Malaria eradication is a global priority but requires innovative strategies. Humoral immune responses attack different parasite stages, and antibody-based therapy may prevent malaria infection or transmission. Here, we discuss targets of monoclonal antibodies in mosquito sexual stages of Plasmodium.

Keywords: malaria; recombinant mAbs; sexual-stage proteins; transmission blocking.

Published by Elsevier Ltd.

Publication types

Research Support, N.I.H., Intramural
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Animals
Antibodies, Monoclonal / immunology*
Culicidae / immunology
Culicidae / parasitology*
Disease Eradication
Humans
Life Cycle Stages / immunology*
Malaria / parasitology
Malaria / prevention & control*
Malaria / transmission*
Plasmodium falciparum / immunology*

Substances

Antibodies, Monoclonal