A deoxyribonuclease 1-like 3 genetic variant associates with asthma exacerbations

J Allergy Clin Immunol. 2021 Mar;147(3):1095-1097.e10. doi: 10.1016/j.jaci.2020.09.027. Epub 2020 Oct 6.

Abstract

The analysis of genetic variants from six genes whose expression is predictive of asthma exacerbations revealed a novel association of a regulatory polymorphism from DNASE1L3 in African-Americans and Latinos.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Asthma / genetics*
  • Black or African American
  • Child
  • Endodeoxyribonucleases / genetics*
  • Female
  • Gene Frequency
  • Genetic Association Studies
  • Genetic Predisposition to Disease
  • Genotype*
  • Hispanic or Latino
  • Humans
  • Male
  • Polymorphism, Single Nucleotide
  • Young Adult

Substances

  • DNASE1L3 protein, human
  • Endodeoxyribonucleases