Diagnostic value of 3D dynamic contrast-enhanced magnetic resonance imaging in lymph node metastases of head and neck tumors: a correlation study with histology

Christoph Treutlein; Adrian Stollberg; Claudia Scherl; Abbas Agaimy; Stephan Ellmann; Heinrich Iro; Michael Lell; Michael Uder; Tobias Bäuerle

doi:10.1177/2058460120951966

Diagnostic value of 3D dynamic contrast-enhanced magnetic resonance imaging in lymph node metastases of head and neck tumors: a correlation study with histology

Acta Radiol Open. 2020 Aug 26;9(8):2058460120951966. doi: 10.1177/2058460120951966. eCollection 2020 Aug.

Authors

Christoph Treutlein¹, Adrian Stollberg¹, Claudia Scherl², Abbas Agaimy³, Stephan Ellmann¹, Heinrich Iro², Michael Lell⁴, Michael Uder¹, Tobias Bäuerle¹

Affiliations

¹ Department of Radiology, University Hospital Erlangen, Erlangen, Germany.
² Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Erlangen, Erlangen, Germany.
³ Institute of Pathology, University Hospital Erlangen, Erlangen, Germany.
⁴ Department of Radiology and Nuclear Medicine, Klinikum Nuremberg, Paracelsus Medical University, Nuremberg, Germany.

Abstract

Background: Accurate staging of cervical lymph nodes (LN) is pivotal for further clinical management of patients with head and neck cancer. Functional magnetic resonance imaging (MRI) such as three-dimensional (3D) dynamic contrast-enhanced (DCE) acquisition might improve the diagnosis of cervical LN metastases.

Purpose: To evaluate the additional diagnostic value of high-resolution 3D T1-weighted DCE in detecting LN metastasis compared to standard morphological imaging criteria in patients with head and neck tumors as correlated to histopathology.

Material and methods: Standard MRI with 3D DCE acquisition at voxel sizes of 1 × 1×1 mm was performed in 15 patients before surgery; 92 LN of the head and neck were histopathologically analyzed. A logistic regression analysis of semi-quantitative DCE parameters, time-intensity curve (TIC) shapes, and morphological criteria was performed to differentiate benign from malignant LN.

Results: Standard MRI was sufficient for diagnosis of malignancy in LN with a short-axis diameter ≥ 15 mm (n = 17). For LN metastases with a short-axis diameter <15 mm (n = 12), however, the combination of 3D DCE MRI parameters, TIC shapes, and LN diameter significantly increased the sensitivity and specificity of diagnosing metastases (DCE + TIC shape + LN diameter: 92% and 88% vs. DCE only: 83% and 68% (P < 0.01) vs. LN diameter only: 83% and 77% (P = 0.04).

Conclusion: MRI including isotropic high-resolution 3D DCE acquisition combined with morphological criteria allows an accurate assessment of small cervical LN metastases in patients with head and neck cancer. For LN ≥ 15 mm diameter, morphologic imaging may suffice to diagnose metastatic disease to the LN.

Keywords: Dynamic contrast-enhanced magnetic resonance imaging; head and neck neoplasms; lymph nodes; lymphatic metastasis; magnetic resonance imaging.