Linkage of genetic drivers and strain-specific germline variants confound mouse cancer genome analyses

Sebastian Mueller; Sebastian Lange; Katharina A N Collins; Stefan Krebs; Helmut Blum; Günter Schneider; Lena Rad; Dieter Saur; Roland Rad

doi:10.1038/s41467-020-18095-3

Linkage of genetic drivers and strain-specific germline variants confound mouse cancer genome analyses

Nat Commun. 2020 Sep 8;11(1):4474. doi: 10.1038/s41467-020-18095-3.

Authors

Sebastian Mueller^#^{1

2}, Sebastian Lange^#^{1

2

3}, Katharina A N Collins^{1

2

3}, Stefan Krebs⁴, Helmut Blum⁴, Günter Schneider³, Lena Rad^{2

5}, Dieter Saur^{2

3

5

6}, Roland Rad^{7

8

9

10}

Affiliations

¹ Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technische Universität München, 81675, Munich, Germany.
² Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technische Universität München, 81675, Munich, Germany.
³ Department of Medicine II, Klinikum rechts der Isar, School of Medicine, Technische Universität München, 81675, Munich, Germany.
⁴ Laboratory for Functional Genome Analysis, Gene Center, Ludwig-Maximilians-Universität München, 81377, Munich, Germany.
⁵ Institute for Experimental Cancer Therapy, School of Medicine, Technische Universität München, 81675, Munich, Germany.
⁶ German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
⁷ Institute of Molecular Oncology and Functional Genomics, School of Medicine, Technische Universität München, 81675, Munich, Germany. roland.rad@tum.de.
⁸ Center for Translational Cancer Research (TranslaTUM), School of Medicine, Technische Universität München, 81675, Munich, Germany. roland.rad@tum.de.
⁹ Department of Medicine II, Klinikum rechts der Isar, School of Medicine, Technische Universität München, 81675, Munich, Germany. roland.rad@tum.de.
¹⁰ German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany. roland.rad@tum.de.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Genetic Linkage
Genome-Wide Association Study*
Germ Cells
Mice
Pancreatic Neoplasms*