Equilibrium, kinetics, thermodynamics and docking studies of Cu2+ ion adsorption over ion-exchange resin and kappa carrageenan blends in blood samples

Pak J Pharm Sci. 2020 Mar;33(2(Supplementary)):795-803.

Abstract

Cupric ions are hazardous to human beings and their removal from the body is very necessary. The blends of IRP69H (AMBERLITE IRP-69 [H+] RESIN), DC20H (DOWEX™ 20 [H+] Resin), DMSCH (DOWEX™ MARATHON™ MSC [H+] Resin) and Kappa Carrageenan (κ-) were utilized for the removal of ions of Cu2+ from the blood. They were subjected to docking studies which showed that there is no significant interaction with the blood albumin. IER dose of 0.5 mg/10mL of IRP69H/κ-, DMSCH/κ-, and DC20H/κ- was essential for the 2+ ion removal. At pH 5.4, optimal 2+ ions adsorption efficiency was attained. The adsorption capacities of 2+ were in the order of IRP69H/κ->DC20H/κ->DMSCH/κ-. While the data fitted well to Freundlich, Langmuir and Dubinin-Radushkevich. Pseudo-second order was followed for 2+ adsorption for DMSCH/κ- and DC20H/κ- while the pseudo-first order was demonstrated well for IRP69H/κ-.

MeSH terms

  • Adsorption
  • Adult
  • Carrageenan / chemistry*
  • Copper / chemistry*
  • Humans
  • Hydrogen-Ion Concentration
  • Ion Exchange Resins / chemistry*
  • Ions / chemistry*
  • Kinetics
  • Resins, Synthetic / chemistry
  • Thermodynamics
  • Water Pollutants, Chemical / chemistry
  • Water Purification / methods
  • Young Adult

Substances

  • Ion Exchange Resins
  • Ions
  • Resins, Synthetic
  • Water Pollutants, Chemical
  • Dowex
  • amberlite IRP 69
  • Copper
  • Carrageenan