Versatile Nickel(II) Scaffolds as Coordination-Induced Spin-State Switches for 19 F Magnetic Resonance-Based Detection

Da Xie; Meng Yu; Zhu-Lin Xie; Rahul T Kadakia; Chris Chung; Lauren E Ohman; Kamyab Javanmardi; Emily L Que

doi:10.1002/anie.202010587

Versatile Nickel(II) Scaffolds as Coordination-Induced Spin-State Switches for ¹⁹ F Magnetic Resonance-Based Detection

Angew Chem Int Ed Engl. 2020 Dec 7;59(50):22523-22530. doi: 10.1002/anie.202010587. Epub 2020 Sep 24.

Authors

Da Xie¹, Meng Yu¹, Zhu-Lin Xie¹, Rahul T Kadakia¹, Chris Chung¹, Lauren E Ohman¹, Kamyab Javanmardi², Emily L Que¹

Affiliations

¹ Department of Chemistry, The University of Texas at Austin, 105 E. 24th St Stop A5300, Austin, TX, 78712, USA.
² Department of Molecular Biosciences, The University of Texas at Austin, 2500 Speedway, Austin, TX, 78712, USA.

PMID: 32790890
DOI: 10.1002/anie.202010587

Abstract

¹⁹ F magnetic resonance (MR) based detection coupled with well-designed inorganic systems shows promise in biological investigations. Two proof-of-concept inorganic probes that exploit a novel mechanism for ¹⁹ F MR sensing based on converting from low-spin (S=0) to high-spin (S=1) Ni²⁺ are reported. Activation of diamagnetic NiL₁ and NiL₂ by light or β-galactosidase, respectively, converts them into paramagnetic NiL₀ , which displays a single ¹⁹ F NMR peak shifted by >35 ppm with accelerated relaxation rates. This spin-state switch is effective for sensing light or enzyme expression in live cells using ¹⁹ F MR spectroscopy and imaging that differentiate signals based on chemical shift and relaxation times. This general inorganic scaffold has potential for developing agents that can sense analytes ranging from ions to enzymes, opening up diverse possibilities for ¹⁹ F MR based biosensing.

Keywords: biosensors; coordination chemistry; fluorine; magnetic resonance spectroscopy; nickel.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Research Support, Non-U.S. Gov't