Is Liver Retransplantation Justified in the Current Era?

Laura Lladó; Josefina Lopez-Dominguez; Emilio Ramos; Alba Cachero; Kristel Mils; Carme Baliellas; Juli Busquets; Joan Fabregat

doi:10.1016/j.ciresp.2020.06.023

Is Liver Retransplantation Justified in the Current Era?

Cir Esp (Engl Ed). 2021 May;99(5):339-345. doi: 10.1016/j.ciresp.2020.06.023. Epub 2020 Aug 3.

[Article in English, Spanish]

Authors

Laura Lladó¹, Josefina Lopez-Dominguez², Emilio Ramos², Alba Cachero², Kristel Mils², Carme Baliellas², Juli Busquets², Joan Fabregat²

Affiliations

¹ Unidad de Trasplante Hepático, Hospital Universitari de Bellvitge, IDIBELL, Barcelona, España. Electronic address: 31513llg@comb.cat.
² Unidad de Trasplante Hepático, Hospital Universitari de Bellvitge, IDIBELL, Barcelona, España.

PMID: 32762955
DOI: 10.1016/j.ciresp.2020.06.023

Abstract

Introduction: Liver retransplantation (LRT) is a controversial indication. Our aim was to evaluate the rate of LRT at our institution, and to analyze its indications and short- and long-term results.

Methods: We conducted a retrospective study of a prospectively collected database, including 1645 LT from 1984 to 2018. Results have been analyzed depending on type of LRT (early vs late), study period and indications.

Results: We performed 150 LRT in 140 patients. The LRT rate was 9%. Of these, 45 LRT were early (30%), and the other 70% were late LRT. The main indications were: ischemic cholangitis (27%), arterial thrombosis (19%), primary non-function (15%), and HCV recurrence (15%). Mean surgery duration (395 vs. 270 min; P = .001), cold ischemia time (435 vs. 390 min; P = .005) and transfused units required (8 vs. 5 RBC; P = .034) were higher in cases of late LRT. Postoperative mortality (10 vs. 20%; P = .01) was better in cases of late LRT. One- and 5-year actuarial survival rates were 71% and 58%, respectively, which were significantly better during the last decade (80% and 64%). Five-year actuarial survival for ischemic cholangitis is better than other indications, such as recurrence of HCV (78 vs. 51%; P = .02).

Conclusions: Liver retransplantation is complex and associated with high morbidity and mortality. However, indications and long-term results have improved during recent years. Therefore, LRT is justified.

Keywords: Colangitis isquémica; Ischemic cholangitis; Liver retransplantation; Morbidity; Morbilidad; Mortalidad; Mortality; Retrasplante hepático; Supervivencia; Survival.