Genetics of tuberous sclerosis complex: an update

Childs Nerv Syst. 2020 Oct;36(10):2489-2496. doi: 10.1007/s00381-020-04726-z. Epub 2020 Aug 6.

Abstract

Purpose: To review the current genetic aspects of tuberous sclerosis complex.

Methods: Review of the literature.

Results: Tuberous sclerosis complex (TSC), a long known childhood-onset monogenic disorder, characterized by hamartoma formation affecting mainly the brain, heart, kidney, lung, and skin, is associated with a high morbidity burden and risk of a reduced life span. The identification of TSC1 and TSC2, as tumor suppressor genes causative of the disorder, led to the elucidation of the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway and its pivotal role in the pathogenesis of hamartoma formation. This knowledge was translated into standard clinical practice with the discovery of rapamycin, and additional analogues, as inhibitors of mTORC1.

Conclusion: Next-generation sequencing was proven to be fundamental to drive research of tumorigenesis in TSC, hopefully leading to new therapeutic options in the future.

Keywords: Hamartoma; TSC1; TSC2; mTOR pathway.

Publication types

  • Review

MeSH terms

  • Child
  • Humans
  • Signal Transduction
  • Sirolimus
  • Tuberous Sclerosis Complex 2 Protein / genetics
  • Tuberous Sclerosis* / genetics
  • Tumor Suppressor Proteins / genetics
  • Tumor Suppressor Proteins / metabolism

Substances

  • Tuberous Sclerosis Complex 2 Protein
  • Tumor Suppressor Proteins
  • Sirolimus