Deactivation of SARS-CoV-2 with pulsed-xenon ultraviolet light: Implications for environmental COVID-19 control

Infect Control Hosp Epidemiol. 2021 Feb;42(2):127-130. doi: 10.1017/ice.2020.399. Epub 2020 Aug 3.

Abstract

Objectives: Prolonged survival of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on environmental surfaces and personal protective equipment may lead to these surfaces transmitting this pathogen to others. We sought to determine the effectiveness of a pulsed-xenon ultraviolet (PX-UV) disinfection system in reducing the load of SARS-CoV-2 on hard surfaces and N95 respirators.

Methods: Chamber slides and N95 respirator material were directly inoculated with SARS-CoV-2 and were exposed to different durations of PX-UV.

Results: For hard surfaces, disinfection for 1, 2, and 5 minutes resulted in 3.53 log10, >4.54 log10, and >4.12 log10 reductions in viral load, respectively. For N95 respirators, disinfection for 5 minutes resulted in >4.79 log10 reduction in viral load. PX-UV significantly reduced SARS-CoV-2 on hard surfaces and N95 respirators.

Conclusion: With the potential to rapidly disinfectant environmental surfaces and N95 respirators, PX-UV devices are a promising technology to reduce environmental and personal protective equipment bioburden and to enhance both healthcare worker and patient safety by reducing the risk of exposure to SARS-CoV-2.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • COVID-19 / prevention & control*
  • COVID-19 / transmission
  • COVID-19 / virology
  • Chlorocebus aethiops
  • Disinfection / instrumentation
  • Disinfection / methods*
  • Equipment Reuse / standards
  • Humans
  • N95 Respirators
  • Personal Protective Equipment
  • SARS-CoV-2 / physiology
  • SARS-CoV-2 / radiation effects*
  • Time Factors
  • Ultraviolet Rays*
  • Vero Cells
  • Xenon

Substances

  • Xenon