Maternal obesity: focus on offspring cardiometabolic outcomes

Alessandra Gambineri; Alessandro Conforti; Andrea Di Nisio; Daniela Laudisio; Giovanna Muscogiuri; Luigi Barrea; Silvia Savastano; Annamaria Colao; Obesity Programs of nutrition, Education, Research and Assessment (OPERA) Group

doi:10.1038/s41367-020-0016-2

Maternal obesity: focus on offspring cardiometabolic outcomes

Int J Obes Suppl. 2020 Jul;10(1):27-34. doi: 10.1038/s41367-020-0016-2. Epub 2020 Jul 20.

Authors

Alessandra Gambineri¹, Alessandro Conforti², Andrea Di Nisio³, Daniela Laudisio⁴, Giovanna Muscogiuri⁴, Luigi Barrea⁴, Silvia Savastano⁴, Annamaria Colao⁴; Obesity Programs of nutrition, Education, Research and Assessment (OPERA) Group

Affiliations

¹ Endocrinology Unit, Department of Medical and Surgical Sciences, St Orsola-Malpighi Hospital, Alma Mater University of Bologna, Bologna, Italy.
² Department of Neuroscience, Reproductive Science and Odontostomatology, University of Naples Federico II, Naples, Italy.
³ Department of Medicine, Operative Unit of Andrology and Medicine of Human Reproduction, University of Padova, Padova, Italy.
⁴ Endocrinology Unit, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.

Abstract

Several human and animal studies have demonstrated that cardiometabolic parameters in infancy, childhood, adolescence and even adulthood are negatively influenced by many factors besides energy imbalance. Interestingly, maternal weight excess both before and during pregnancy seems to be a negative determinant of metabolic and cardiovascular outcomes in the offspring. This review includes both human and animal studies and finally highlights the link between maternal obesity and cardiometabolic disorders in offspring.

Publication types

Review