National Surveillance of Antimicrobial Susceptibility of Bacteremic Gram-Negative Bacteria with Emphasis on Community-Acquired Resistant Isolates: Report from the 2019 Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART)

Po-Yu Liu; Yu-Lin Lee; Min-Chi Lu; Pei-Lan Shao; Po-Liang Lu; Yen-Hsu Chen; Shu-Hsing Cheng; Wen-Chien Ko; Chi-Ying Lin; Ting-Shu Wu; Muh-Yong Yen; Lih-Shinn Wang; Chang-Pan Liu; Wen-Sen Lee; Yao-Shen Chen; Fu-Der Wang; Shu-Hui Tseng; Chao-Nan Lin; Hung-Jen Tang; Yu-Hui Chen; Wang-Huei Sheng; Chun-Ming Lee; Ming-Huei Liao; Po-Ren Hsueh

doi:10.1128/AAC.01089-20

National Surveillance of Antimicrobial Susceptibility of Bacteremic Gram-Negative Bacteria with Emphasis on Community-Acquired Resistant Isolates: Report from the 2019 Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART)

Antimicrob Agents Chemother. 2020 Sep 21;64(10):e01089-20. doi: 10.1128/AAC.01089-20. Print 2020 Sep 21.

Authors

Po-Yu Liu¹, Yu-Lin Lee², Min-Chi Lu³, Pei-Lan Shao⁴, Po-Liang Lu⁵, Yen-Hsu Chen⁵, Shu-Hsing Cheng^{6

7}, Wen-Chien Ko⁸, Chi-Ying Lin⁹, Ting-Shu Wu¹⁰, Muh-Yong Yen¹¹, Lih-Shinn Wang¹², Chang-Pan Liu^{13

14}, Wen-Sen Lee^{15

16}, Yao-Shen Chen^{17

18}, Fu-Der Wang^{19

18}, Shu-Hui Tseng²⁰, Chao-Nan Lin^{21

22}, Hung-Jen Tang²³, Yu-Hui Chen^{24

25}, Wang-Huei Sheng²⁶, Chun-Ming Lee^{27

28}, Ming-Huei Liao²⁹, Po-Ren Hsueh^{30

31}

Affiliations

¹ Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
² Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan.
³ Department of Microbiology and Immunology, School of Medicine, China Medical University, Taichung, Taiwan.
⁴ Department of Pediatrics, Hsin-Chu Branch, National Taiwan University Hospital, Hsin-Chu, Taiwan.
⁵ Department of Internal Medicine, Kaohsiung Medical University Hospital, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
⁶ Department of Internal Medicine, Taoyuan General Hospital, Ministry of Health Welfare, Taoyuan, Taiwan.
⁷ School of Public Health, College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan.
⁸ Department of Internal Medicine, National Cheng Kung University Medical College and Hospital, Tainan, Taiwan.
⁹ Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin, Taiwan.
¹⁰ Division of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine, Taoyuan, Taiwan.
¹¹ Division of Infectious Diseases, Taipei City Hospital, and National Yang-Ming University, School of Medicine, Taipei, Taiwan.
¹² Division of Infectious Diseases, Department of Internal Medicine, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan.
¹³ Division of Infectious Diseases, Department of Internal Medicine, MacKay Memorial Hospital, Taipei, Taiwan.
¹⁴ MacKay Medical College, New Taipei City, Taiwan.
¹⁵ Division of Infectious Diseases, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
¹⁶ Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
¹⁷ Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
¹⁸ School of Medicine, National Yang-Ming University, Taipei, Taiwan.
¹⁹ Division of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
²⁰ Centers for Disease Control and Prevention, Ministry of Health and Welfare, Taipei, Taiwan.
²¹ Department of Veterinary Medicine, College of Veterinary Medicine, National Pingtung University of Science and Technology, Pingtung, Taiwan.
²² Animal Disease Diagnostic Center, College of Veterinary Medicine, National Pingtung University of Science and Technology, Pingtung, Taiwan.
²³ Department of Medicine, Chi Mei Medical Center, Tainan, Taiwan.
²⁴ Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
²⁵ School of Medicine, Graduate Institute of Medicine, Sepsis Research Center, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
²⁶ Division of Infectious Disease, Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan.
²⁷ Department of Internal Medicine, St. Joseph's Hospital, Yunlin County, Taiwan.
²⁸ MacKay Junior College of Medicine, Nursing, and Management, Taipei, Taiwan.
²⁹ National Pingtung University of Science and Technology, Neipu, Taiwan.
³⁰ Division of Infectious Disease, Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan hsporen@ntu.edu.tw.
³¹ Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan.

Abstract

A multicenter collection of bacteremic isolates of Escherichia coli (n = 423), Klebsiella pneumoniae (n = 372), Pseudomonas aeruginosa (n = 300), and Acinetobacter baumannii complex (n = 199) was analyzed for susceptibility. Xpert Carba-R assay and sequencing for mcr genes were performed for carbapenem- or colistin-resistant isolates. Nineteen (67.8%) carbapenem-resistant K. pneumoniae (n = 28) and one (20%) carbapenem-resistant E. coli (n = 5) isolate harbored bla_KPC (n = 17), bla_OXA-48 (n = 2), and bla_VIM (n = 1) genes.

Keywords: Enterobacteriaceae; KPC; carbapenemases; colistin; mcr-1.

Publication types

Multicenter Study
Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents* / pharmacology
Bacterial Proteins / genetics
Drug Resistance, Bacterial / genetics
Escherichia coli / genetics
Gram-Negative Bacteria / genetics
Microbial Sensitivity Tests
Taiwan
beta-Lactamases* / genetics

Substances

Anti-Bacterial Agents
Bacterial Proteins
beta-Lactamases