Clinical Phenotype and Genetic Features of a Pair of Chinese Twins with Kearns-Sayre Syndrome

DNA Cell Biol. 2020 Aug;39(8):1449-1457. doi: 10.1089/dna.2019.5010. Epub 2020 Jun 29.

Abstract

Kearns-Sayre Syndrome (KSS) is a severe mitochondrial disorder involving the central nervous system, eyes, ears, skeletal muscles, and heart. The mitochondrial DNA (mtDNA) rearrangements, especially the deletions, are present in almost all KSS patients and considered as the disease-causing factor. However, the size and position of mtDNA deletions are distinct in different individuals. In this study, we report the case of a pair of Chinese twins with KSS. The twin patients revealed typical KSS clinical symptoms, including heart block, bilateral sensorineural hearing loss, progressive external ophthalmoplegia, exercise intolerance, proximal limb weakness, and endocrine disorders. Using long-range polymerase chain reactions (long-range PCR) and next-generation sequencing (NGS), the genetic features of the twin patients were investigated. A large 6600 bp mtDNA deletion, ranging from position 8702 to 15,302, was detected in both patients. To our knowledge, this kind of mtDNA deletion has never been described previously. Our study enriched the mutation spectrum of KSS and showed that NGS is a powerful tool for detecting mtDNA large variants.

Keywords: Kearns–Sayre Syndrome; deletion; mitochondrial disease.

MeSH terms

  • Central Nervous System / pathology
  • Child
  • Chromosomes / genetics
  • DNA, Mitochondrial / genetics*
  • Diseases in Twins / genetics*
  • Diseases in Twins / pathology
  • Ear / pathology
  • Eye / pathology
  • Gene Deletion
  • Genetic Predisposition to Disease
  • Heart / physiopathology
  • Humans
  • Kearns-Sayre Syndrome / genetics*
  • Kearns-Sayre Syndrome / pathology
  • Male
  • Muscle, Skeletal / metabolism
  • Muscle, Skeletal / pathology
  • Mutation / genetics
  • Ophthalmoplegia, Chronic Progressive External / genetics*
  • Ophthalmoplegia, Chronic Progressive External / pathology
  • Phenotype

Substances

  • DNA, Mitochondrial