Background: Paraneoplastic Raynaud's phenomenon is a rare complication occurring in patients with advanced cancer.
Methods: We present a case of a patient with breast cancer and presenting with acrocyanosis evolving into necrosis as a paraneoplastic phenomenon in progressive breast cancer.
Results: Unless a multidisciplinary approach was taken, improvement of the symptoms was only seen with prostacyclin analogs, and cancer treatment needed to be changed because of rapidly progressing disease.
Conclusion: Paraneoplastic Raynaud's phenomenon is a rare but severe presentation of advanced and progressive cancer. Treatment with intravenous prostacyclin analogs should be considered and a multidisciplinary approach is necessary.
Keywords: Raynaud’s phenomenon; acrocyanosis; advanced cancer; breast cancer; paraneoplastic.