Personalized Nutrition for Management of Micronutrient Deficiency-Literature Review in Non-bariatric Populations and Possible Utility in Bariatric Cohort

Obes Surg. 2020 Sep;30(9):3570-3582. doi: 10.1007/s11695-020-04762-3. Epub 2020 Jun 20.

Abstract

Background: Bariatric surgery can effectively treat morbid obesity; however, micronutrient deficiencies are common despite recommendations for high-dose supplements. Genetic predisposition to deficiencies underscores necessary identification of high-risk candidates. Personalized nutrition (PN) can be a tool to manage these deficiencies.

Methods: Medline, PubMed, and Google Scholar were searched. Articles involving genetic testing, micronutrient metabolism, and bariatric surgery were included.

Results: Studies show associations between genetic variants and micronutrient metabolism. Research demonstrates genetic testing to be a predictor for outcomes among obesity and bariatric surgery populations. There is limited research in bariatric surgery and micronutrient genetic variants.

Conclusion: Genotype-based PN is becoming feasible to provide an effective treatment of micronutrient deficiencies associated with bariatric surgery. The role of genomic technology in micronutrient recommendations needs further investigation.

Keywords: Deficiency; Gene; Gene expression; Nutrients; Obesity; Polymorphism; Supplementation.

Publication types

  • Review

MeSH terms

  • Bariatric Surgery*
  • Humans
  • Malnutrition*
  • Micronutrients
  • Nutritional Status
  • Obesity, Morbid* / surgery

Substances

  • Micronutrients