Chemical purification of 111Ag from isobaric impurity 111Cd by solid phase extraction chromatography: a proof of concept study

Marianna Tosato; Sonia Nardella; Denis Badocco; Paolo Pastore; Alberto Andrighetto; Nicola Realdon; Valerio Di Marco

doi:10.1016/j.apradiso.2020.109263

Chemical purification of ¹¹¹Ag from isobaric impurity ¹¹¹Cd by solid phase extraction chromatography: a proof of concept study

Appl Radiat Isot. 2020 Oct:164:109263. doi: 10.1016/j.apradiso.2020.109263. Epub 2020 Jun 9.

Authors

Marianna Tosato¹, Sonia Nardella¹, Denis Badocco¹, Paolo Pastore¹, Alberto Andrighetto², Nicola Realdon³, Valerio Di Marco⁴

Affiliations

¹ Department of Chemical Sciences, University of Padova, Via Marzolo 1, 35131, Padova, Italy.
² Italian Institute of Nuclear Physics, Legnaro National Laboratories, Viale dell'Università 2, 35020, Legnaro, Padova, Italy.
³ Department of Pharmaceutical Sciences, University of Padova, Via Marzolo 5, 35131, Padova, Italy.
⁴ Department of Chemical Sciences, University of Padova, Via Marzolo 1, 35131, Padova, Italy. Electronic address: valerio.dimarco@unipd.it.

PMID: 32554124
DOI: 10.1016/j.apradiso.2020.109263

Abstract

Silver-111 (¹¹¹Ag, t_1/2 = 7.47 d) is a β^- emitter suitable for targeted cancer therapy due to favourable decay properties. The production of no-carrier added ¹¹¹Ag via Isotope Separation On-Line (ISOL) technique is being investigated at the Legnaro National Laboratories of the Italian Institute of Nuclear Physics (ISOLPHARM project). Stable Cadmium-111 (¹¹¹Cd) is co-produced as isobaric contaminant, hence a chemical separation process must be developed to selectively harvest ¹¹¹Ag. In this study, a chromatographic procedure employing the commercially available CL resin was investigated by using stable Ag⁺ and Cd²⁺. Results indicate that CL resin allows to efficiently separate Ag⁺ from Cd²⁺ and recover the former with high yields.

Keywords: CL resin; Cadmium; Extraction chromatography; ISOLPHARM; Silver.

MeSH terms

Proof of Concept Study
Radioisotopes / isolation & purification*
Silver / isolation & purification*
Solid Phase Extraction / methods*

Substances

Radioisotopes
Silver