Characteristics, Cardiac Involvement, and Outcomes of Multisystem Inflammatory Syndrome of Childhood Associated with severe acute respiratory syndrome coronavirus 2 Infection

J Pediatr. 2020 Sep:224:141-145. doi: 10.1016/j.jpeds.2020.06.044. Epub 2020 Jun 14.

Abstract

We report on the presentation and course of 33 children with multisystem inflammatory syndrome in children and confirmed severe acute respiratory syndrome coronavirus 2 infection. Hemodynamic instability and cardiac dysfunction were prominent findings, with most patients exhibiting rapid resolution following anti-inflammatory therapy.

Keywords: adolescents; coronary aneurysm; inflammation; kawasaki disease.

MeSH terms

  • Adolescent
  • Anti-Inflammatory Agents / therapeutic use
  • Betacoronavirus
  • COVID-19
  • COVID-19 Drug Treatment
  • Child
  • Child, Preschool
  • Coronary Aneurysm
  • Coronavirus Infections / complications*
  • Coronavirus Infections / drug therapy
  • Female
  • Fever
  • Humans
  • Inflammation
  • Male
  • Mucocutaneous Lymph Node Syndrome / diagnosis
  • New York City
  • Pandemics
  • Pneumonia, Viral / complications*
  • Retrospective Studies
  • SARS-CoV-2
  • Shock / complications
  • Systemic Inflammatory Response Syndrome / diagnosis*
  • Systemic Inflammatory Response Syndrome / therapy*
  • Treatment Outcome
  • Ventricular Dysfunction, Left / complications

Substances

  • Anti-Inflammatory Agents

Supplementary concepts

  • pediatric multisystem inflammatory disease, COVID-19 related