COVID-19 is more severe in patients with hypertension; ACEI/ARB treatment does not influence clinical severity and outcome

Jianhua Hu; Xiaoli Zhang; Xuan Zhang; Hong Zhao; Jiangshan Lian; Shaorui Hao; Hongyu Jia; Meifang Yang; Yingfeng Lu; Dairong Xiang; Huan Cai; Shanyan Zhang; Jueqing Gu; Chanyuan Ye; Guodong Yu; Ciliang Jin; Lin Zheng; Yida Yang; Jifang Sheng

doi:10.1016/j.jinf.2020.05.056

COVID-19 is more severe in patients with hypertension; ACEI/ARB treatment does not influence clinical severity and outcome

J Infect. 2020 Dec;81(6):979-997. doi: 10.1016/j.jinf.2020.05.056. Epub 2020 May 28.

Authors

Jianhua Hu¹, Xiaoli Zhang², Xuan Zhang³, Hong Zhao⁴, Jiangshan Lian⁵, Shaorui Hao⁶, Hongyu Jia⁷, Meifang Yang⁸, Yingfeng Lu⁹, Dairong Xiang¹⁰, Huan Cai¹¹, Shanyan Zhang¹², Jueqing Gu¹³, Chanyuan Ye¹⁴, Guodong Yu¹⁵, Ciliang Jin¹⁶, Lin Zheng¹⁷, Yida Yang¹⁸, Jifang Sheng¹⁹

Affiliations

¹ State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 QingChun Road, Hangzhou, Zhejiang, 310003, China. Electronic address: hjianhua0825@zju.edu.cn.
² State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 QingChun Road, Hangzhou, Zhejiang, 310003, China. Electronic address: 11918240@zju.edu.cn.
³ State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 QingChun Road, Hangzhou, Zhejiang, 310003, China. Electronic address: keaihongcha@163.com.
⁴ State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 QingChun Road, Hangzhou, Zhejiang, 310003, China. Electronic address: zjuzhaohong@zju.edu.cn.
⁵ State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 QingChun Road, Hangzhou, Zhejiang, 310003, China. Electronic address: lianjiangshan@zju.edu.cn.
⁶ State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 QingChun Road, Hangzhou, Zhejiang, 310003, China. Electronic address: haoshaorui@zju.edu.cn.
⁷ State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 QingChun Road, Hangzhou, Zhejiang, 310003, China. Electronic address: jhy@zju.edu.cn.
⁸ State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 QingChun Road, Hangzhou, Zhejiang, 310003, China. Electronic address: rosemary1978@163.com.
⁹ State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 QingChun Road, Hangzhou, Zhejiang, 310003, China. Electronic address: andy_feng807@sina.com.
¹⁰ State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 QingChun Road, Hangzhou, Zhejiang, 310003, China. Electronic address: 1509023@zju.edu.cn.
¹¹ State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 QingChun Road, Hangzhou, Zhejiang, 310003, China. Electronic address: 11718323@zju.edu.cn.
¹² State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 QingChun Road, Hangzhou, Zhejiang, 310003, China. Electronic address: 1125shanyan@zju.edu.cn.
¹³ State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 QingChun Road, Hangzhou, Zhejiang, 310003, China. Electronic address: 21718047@zju.edu.cn.
¹⁴ State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 QingChun Road, Hangzhou, Zhejiang, 310003, China. Electronic address: 21818050@zju.edu.cn.
¹⁵ State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 QingChun Road, Hangzhou, Zhejiang, 310003, China. Electronic address: 3090103834@zju.edu.cn.
¹⁶ State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 QingChun Road, Hangzhou, Zhejiang, 310003, China. Electronic address: 11918235@zju.edu.cn.
¹⁷ State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 QingChun Road, Hangzhou, Zhejiang, 310003, China. Electronic address: zhenglin2005@163.com.
¹⁸ State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 QingChun Road, Hangzhou, Zhejiang, 310003, China. Electronic address: yangyida65@163.com.
¹⁹ State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 QingChun Road, Hangzhou, Zhejiang, 310003, China. Electronic address: jifang_sheng@zju.edu.cn.

No abstract available

Keywords: Angiotensin receptor blocker (ARB); Angiotensin-converting enzyme inhibitor (ACEI); Coronavirus disease 2019 (COVID-19); Hypertention; Outcome; Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Angiotensin Receptor Antagonists / adverse effects
Angiotensin Receptor Antagonists / therapeutic use*
Angiotensin-Converting Enzyme Inhibitors / adverse effects
Angiotensin-Converting Enzyme Inhibitors / therapeutic use*
COVID-19 / epidemiology*
COVID-19 Drug Treatment
China
Female
Humans
Hypertension / drug therapy*
Hypertension / epidemiology
Male
Middle Aged
SARS-CoV-2
Severity of Illness Index
Treatment Outcome

Substances

Angiotensin Receptor Antagonists
Angiotensin-Converting Enzyme Inhibitors