Intelligent image-based deformation-assisted cell sorting with molecular specificity

Nat Methods. 2020 Jun;17(6):595-599. doi: 10.1038/s41592-020-0831-y. Epub 2020 May 25.

Abstract

Although label-free cell sorting is desirable for providing pristine cells for further analysis or use, current approaches lack molecular specificity and speed. Here, we combine real-time fluorescence and deformability cytometry with sorting based on standing surface acoustic waves and transfer molecular specificity to image-based sorting using an efficient deep neural network. In addition to general performance, we demonstrate the utility of this method by sorting neutrophils from whole blood without labels.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Culture Techniques
  • Cell Line
  • Cell Proliferation
  • Cell Size
  • Cell Survival
  • Drosophila / cytology
  • Erythrocyte Deformability
  • Erythrocytes / cytology
  • Flow Cytometry / methods*
  • HL-60 Cells
  • Humans
  • Microfluidics / methods*
  • Myeloid Cells / cytology
  • Neural Networks, Computer*
  • Neutrophils / cytology
  • Sound

Associated data

  • figshare/10.6084/m9.figshare.11302595