PHLD Class Proteins: A Family of New Players in the p53 Network

Int J Mol Sci. 2020 May 17;21(10):3543. doi: 10.3390/ijms21103543.

Abstract

The Pleckstrin Homology-like Domain (PHLD) class of proteins are multifunctional proteins. The class is comprised of two families of proteins, PHLDA and PHLDB, each with 3 members. All members of the families possess a pleckstrin homology (PH) domain. Though identified nearly 30 years ago, this class of proteins remains understudied with PHLDA family members receiving most of the research attention. Recent studies have also begun to reveal the functions of the PHLDB family proteins in regulation of p53 and AKT signaling pathways important for cancer and metabolism. This review will discuss current research and offer some prospects on the possible roles of both families in cancer and metabolism.

Keywords: AKT signaling; PHLDA; PHLDB; cancer; metabolism; p53.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Neoplasms / genetics
  • Neoplasms / metabolism*
  • Pleckstrin Homology Domains / genetics*
  • Protein Binding
  • Proto-Oncogene Proteins c-akt / genetics
  • Proto-Oncogene Proteins c-akt / metabolism*
  • Signal Transduction / genetics*
  • Tumor Suppressor Protein p53 / genetics
  • Tumor Suppressor Protein p53 / metabolism*

Substances

  • Tumor Suppressor Protein p53
  • Proto-Oncogene Proteins c-akt