Connecting Pathological Cellular Mechanisms to Large-Scale Seizure Structures

Quynh-Anh Nguyen; Prannath Moolchand; Ivan Soltesz

doi:10.1016/j.tins.2020.04.006

Connecting Pathological Cellular Mechanisms to Large-Scale Seizure Structures

Trends Neurosci. 2020 Aug;43(8):547-549. doi: 10.1016/j.tins.2020.04.006. Epub 2020 May 3.

Authors

Quynh-Anh Nguyen¹, Prannath Moolchand¹, Ivan Soltesz²

Affiliations

¹ Department of Neurosurgery, Stanford University, Stanford, CA 94305, USA.
² Department of Neurosurgery, Stanford University, Stanford, CA 94305, USA. Electronic address: isoltesz@stanford.edu.

Abstract

Epilepsy is a neurological disorder characterized by recurrent seizures, where abnormal electrical activity begins in a local brain area and propagates before terminating. In a recent study, Liou and colleagues used multiscale computational modeling to gain mechanistic insights into clinical seizure dynamics based on cellular-level biophysical properties.

Keywords: GABA; computational modeling; epilepsy; excitation; inhibition; seizure dynamics.

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MeSH terms

Brain
Epilepsy*
Epilepsy, Generalized*
Humans
Models, Neurological
Seizures

Abstract

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MeSH terms

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