Abstract
We report acute antibody responses to SARS-CoV-2 in 285 patients with COVID-19. Within 19 days after symptom onset, 100% of patients tested positive for antiviral immunoglobulin-G (IgG). Seroconversion for IgG and IgM occurred simultaneously or sequentially. Both IgG and IgM titers plateaued within 6 days after seroconversion. Serological testing may be helpful for the diagnosis of suspected patients with negative RT-PCR results and for the identification of asymptomatic infections.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Antibodies, Viral / blood*
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Antibody Formation / drug effects*
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Antibody Formation / immunology
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Antiviral Agents / therapeutic use
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Betacoronavirus / genetics
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Betacoronavirus / pathogenicity*
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COVID-19
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Coronavirus Infections / blood
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Coronavirus Infections / drug therapy*
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Coronavirus Infections / immunology
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Coronavirus Infections / virology
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Female
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Humans
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Immunoglobulin G / blood
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Immunoglobulin M / blood
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Male
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Middle Aged
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Pandemics / prevention & control
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Pneumonia, Viral / blood
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Pneumonia, Viral / drug therapy*
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Pneumonia, Viral / immunology
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Pneumonia, Viral / virology
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SARS-CoV-2
Substances
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Antibodies, Viral
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Antiviral Agents
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Immunoglobulin G
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Immunoglobulin M