Concurrent ERBB2 missense mutations D769Y and D742 N Are Novel Acquired Mechanism of Gefitinib Resistance but Responds to Gefitinib plus Pyrotinib

Lung Cancer. 2020 Jun:144:90-91. doi: 10.1016/j.lungcan.2020.04.003. Epub 2020 Apr 13.
No abstract available

Publication types

  • Letter

MeSH terms

  • Acrylamides
  • Aminoquinolines
  • Drug Resistance, Neoplasm / genetics
  • Gefitinib / pharmacology
  • Gefitinib / therapeutic use
  • Humans
  • Lung Neoplasms* / drug therapy
  • Lung Neoplasms* / genetics
  • Mutation, Missense*
  • Receptor, ErbB-2 / genetics

Substances

  • Acrylamides
  • Aminoquinolines
  • pyrotinib
  • ERBB2 protein, human
  • Receptor, ErbB-2
  • Gefitinib