Multifaceted transforming growth factor-beta (TGFβ) signalling in glioblastoma

Joanna L Birch; Barry J Coull; Lindsay C Spender; Courtney Watt; Alice Willison; Nelofer Syed; Anthony J Chalmers; M Kismet Hossain-Ibrahim; Gareth J Inman

doi:10.1016/j.cellsig.2020.109638

Multifaceted transforming growth factor-beta (TGFβ) signalling in glioblastoma

Cell Signal. 2020 Aug:72:109638. doi: 10.1016/j.cellsig.2020.109638. Epub 2020 Apr 19.

Authors

Joanna L Birch¹, Barry J Coull², Lindsay C Spender³, Courtney Watt², Alice Willison², Nelofer Syed⁴, Anthony J Chalmers⁵, M Kismet Hossain-Ibrahim⁶, Gareth J Inman⁷

Affiliations

¹ CRUK Beatson Institute, Glasgow, UK.
² Division of Cellular and Molecular Medicine, School of Medicine, University of Dundee, Dundee, UK.
³ Division of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Dundee, UK.
⁴ The John Fulcher Molecular Neuro-Oncology Laboratory, Division of Brain Sciences, Imperial College London, London, UK.
⁵ Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.
⁶ Division of Cellular and Molecular Medicine, School of Medicine, University of Dundee, Dundee, UK; Department of Neurosurgery, Ninewells Hospital and Medical School, NHS Tayside, Dundee, UK.
⁷ CRUK Beatson Institute, Glasgow, UK; Division of Cellular and Molecular Medicine, School of Medicine, University of Dundee, Dundee, UK; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK. Electronic address: gareth.inman@glasgow.ac.uk.

PMID: 32320860
DOI: 10.1016/j.cellsig.2020.109638

Abstract

Glioblastoma (GBM) is an aggressive and devastating primary brain cancer which responds very poorly to treatment. The average survival time of patients is only 14-15 months from diagnosis so there is a clear and unmet need for the development of novel targeted therapies to improve patient outcomes. The multifunctional cytokine TGFβ plays fundamental roles in development, adult tissue homeostasis, tissue wound repair and immune responses. Dysfunction of TGFβ signalling has been implicated in both the development and progression of many tumour types including GBM, thereby potentially providing an actionable target for its treatment. This review will examine TGFβ signalling mechanisms and their role in the development and progression of GBM. The targeting of TGFβ signalling using a variety of approaches including the TGFβ binding protein Decorin will be highlighted as attractive therapeutic strategies.

Keywords: Decorin; Glioblastoma; Transforming growth factor beta.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Brain Neoplasms / drug therapy
Brain Neoplasms / metabolism*
Decorin / metabolism
Glioblastoma / drug therapy
Glioblastoma / metabolism*
Humans
Signal Transduction*
Transforming Growth Factor beta / metabolism*
Tumor Microenvironment

Substances

Decorin
Transforming Growth Factor beta

Abstract

Publication types

MeSH terms

Substances

Grants and funding