SLeuthing Tuberculous Cough

Marcel A Behr; Paul H Edelstein; Lalita Ramakrishnan

doi:10.1016/j.cell.2020.03.057

SLeuthing Tuberculous Cough

Cell. 2020 Apr 16;181(2):230-232. doi: 10.1016/j.cell.2020.03.057.

Authors

Marcel A Behr¹, Paul H Edelstein², Lalita Ramakrishnan³

Affiliations

¹ Department of Medicine, McGill University, McGill International TB Centre, Montreal H4A 3J1, Canada. Electronic address: marcel.behr@mcgill.ca.
² Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK. Electronic address: paul.edelstein@pennmedicine.upenn.edu.
³ Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK. Electronic address: lr404@cam.ac.uk.

PMID: 32302566
DOI: 10.1016/j.cell.2020.03.057

Abstract

Cough, a hallmark of tuberculosis, transmits the disease. Ruhl et al. find that a Mycobacterium tuberculosis (Mtb)-specific lipid, SL-1, stimulates human nociceptive neurons and makes guinea pigs cough. Mtb extract, but not SL-1, also stimulates non-nociceptive neurons that participate in the cough reflex, suggesting additional cough-inducing mechanisms.

Publication types

Comment

MeSH terms

Animals
Cough
Guinea Pigs
Humans
Lipids
Mycobacterium tuberculosis*
Nociceptors
Tuberculosis*

Substances

Lipids
sulfolipids

Grants and funding

R37 AI054503/AI/NIAID NIH HHS/United States