Targeted gene silencing in vivo by platelet membrane-coated metal-organic framework nanoparticles

Sci Adv. 2020 Mar 27;6(13):eaaz6108. doi: 10.1126/sciadv.aaz6108. eCollection 2020 Mar.

Abstract

Small interfering RNA (siRNA) is a powerful tool for gene silencing that has been used for a wide range of biomedical applications, but there are many challenges facing its therapeutic use in vivo. Here, we report on a platelet cell membrane-coated metal-organic framework (MOF) nanodelivery platform for the targeted delivery of siRNA in vivo. The MOF core is capable of high loading yields, and its pH sensitivity enables endosomal disruption upon cellular uptake. The cell membrane coating provides a natural means of biointerfacing with disease substrates. It is shown that high silencing efficiency can be achieved in vitro against multiple target genes. Using a murine xenograft model, significant antitumor targeting and therapeutic efficacy are observed. Overall, the biomimetic nanodelivery system presented here provides an effective means of achieving gene silencing in vivo and could be used to expand the applicability of siRNA across a range of disease-relevant applications.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Blood Platelets / metabolism*
  • Cell Line, Tumor
  • Cell Membrane / metabolism*
  • Coated Vesicles / metabolism*
  • Drug Carriers
  • Gene Knockdown Techniques
  • Gene Silencing*
  • Gene Transfer Techniques
  • Genes, Reporter
  • Humans
  • Metal Nanoparticles*
  • Metal-Organic Frameworks*
  • Mice
  • RNA, Small Interfering
  • Survivin / genetics
  • Survivin / metabolism
  • Xenograft Model Antitumor Assays

Substances

  • BIRC5 protein, human
  • Drug Carriers
  • Metal-Organic Frameworks
  • RNA, Small Interfering
  • Survivin