Why is Listeria monocytogenes such a potent inducer of CD8+ T-cells?

Cell Microbiol. 2020 Apr;22(4):e13175. doi: 10.1111/cmi.13175.

Abstract

Listeria monocytogenes is a rapidly growing, Gram-positive, facultative intracellular pathogen that has been used for over 5 decades as a model to study basic aspects of infection and immunity. In a murine intravenous infection model, immunisation with a sublethal infection of L. monocytogenes initially leads to rapid intracellular multiplication followed by clearance of the bacteria and ultimately culminates in the development of long-lived cell-mediated immunity (CMI) mediated by antigen-specific CD8+ cytotoxic T-cells. Importantly, effective immunisation requires live, replicating bacteria. In this review, we summarise the cell and immunobiology of L. monocytogenes infection and discuss aspects of its pathogenesis that we suspect lead to robust CMI. We suggest five specific features of L. monocytogenes infection that positively impact the development of CMI: (a) the bacteria have a predilection for professional antigen-presenting cells; (b) the bacteria escape from phagosomes, grow, and secrete antigens into the host cell cytosol; (c) bacterial-secreted proteins enter the major histocompatibility complex (MHC) class I pathway of antigen processing and presentation; (d) the bacteria do not induce rapid host cell death; and (e) cytosolic bacteria induce a cytokine response that favours CMI. Collectively, these features make L. monocytogenes an attractive vaccine vector for both infectious disease applications and cancer immunotherapy.

Keywords: bacteria; cancer; dendritic cell; inflammasome; intracellular pathogen; macrophage; tumour; vaccine.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • CD8-Positive T-Lymphocytes / immunology*
  • Cytokines / immunology
  • Cytosol / immunology
  • Cytosol / microbiology
  • Host-Pathogen Interactions
  • Humans
  • Immunity, Cellular*
  • Listeria monocytogenes / immunology*
  • Listeria monocytogenes / pathogenicity
  • Listeriosis / immunology*
  • Mice
  • Phagosomes / microbiology
  • T-Lymphocytes, Cytotoxic / immunology

Substances

  • Cytokines