Abstract
In a double-blind, randomized study, 500 premature infants were treated with plasminogen or placebo intravenously within 60 minutes of birth. There was a substantial decrease in severe clinical respiratory distress, death caused by hyaline membrane disease, and total mortality in the plasminogen-treated infants as compared to the controls.
Publication types
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Clinical Trial
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Randomized Controlled Trial
MeSH terms
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Clinical Trials as Topic
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Female
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Fibrin / metabolism
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Fibrinolysis / drug effects
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Gestational Age
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Humans
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Hyaline Membrane Disease / metabolism
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Hyaline Membrane Disease / prevention & control*
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Infant, Newborn
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Injections, Intravenous
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Male
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Plasminogen / administration & dosage
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Plasminogen / pharmacology
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Plasminogen / therapeutic use*
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Pulmonary Alveoli / metabolism