Hyaluronic acid functionalized gold nanorods combined with copper-based therapeutic agents for chemo-photothermal cancer therapy

J Mater Chem B. 2020 Jun 10;8(22):4841-4845. doi: 10.1039/d0tb00097c.

Abstract

We herein report a hybrid nanocomposite (AuNRs-CTN@THA) which is based on hyaluronic acid-coated gold nanorods with loading of a copper complex through strong bonds. AuNRs-CTN@THA exhibits durable photothermal conversion capacity for pH-dominant and pH/temperature dual sensitive drug release, accomplishing synergetic antitumor efficacy and deep tumor penetration.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Cell Survival / drug effects
  • Copper / chemistry
  • Copper / pharmacology*
  • Drug Screening Assays, Antitumor
  • Gold / chemistry
  • Gold / pharmacology*
  • Hyaluronic Acid / chemistry
  • Hyaluronic Acid / pharmacology*
  • Mice
  • Nanotubes / chemistry
  • Particle Size
  • Photothermal Therapy*
  • Surface Properties

Substances

  • Antineoplastic Agents
  • Gold
  • Copper
  • Hyaluronic Acid