Development and Longevity: Cellular and Molecular Determinants - A Mini-Review

Silvia Marchionni; Christian Sell; Antonello Lorenzini

doi:10.1159/000505327

Development and Longevity: Cellular and Molecular Determinants - A Mini-Review

Gerontology. 2020;66(3):223-230. doi: 10.1159/000505327. Epub 2020 Feb 7.

Authors

Silvia Marchionni¹, Christian Sell², Antonello Lorenzini³

Affiliations

¹ Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy.
² Department of Biochemistry & Molecular Biology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA.
³ Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy, antonello.lorenzini@unibo.it.

PMID: 32036369
DOI: 10.1159/000505327

Abstract

Across species, development and longevity are tightly linked. We discuss the relevant literature and suggest that the root for this stringent relationship is the rate of development. The basis for the relationship between rate of development and longevity lies in adaptations that have occurred through evolution at multiple levels of biological complexity: organism, organ, cellular, and molecular. Thus, the analysis of the relationship is of interest for multiple fields of biology.

Keywords: Aging; Caloric restriction; DNA damage; Development; Growth rate; IGF-1; Longevity; Senescence; Telomere.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Aging / physiology*
Animals
Cellular Senescence / physiology
Humans
Longevity / physiology*
Telomere / physiology