Recommendations for the use of Japanese encephalitis vaccines

Ping-Ing Lee; Yhu-Chering Huang; Kao-Pin Hwang; Ching-Chuan Liu; Cheng-Hsun Chiu; Po-Yen Chen; Chun-Yi Lu; Chih-Jung Chen; Luan-Yin Chang; Nan-Chang Chiu; Hsin Chi; Hsiao-Chuan Lin; Keh-Gong Wu; Yu-Huai Ho; Wu Sun; Tzou-Yien Lin

doi:10.1016/j.pedneo.2019.11.009

Recommendations for the use of Japanese encephalitis vaccines

Pediatr Neonatol. 2020 Feb;61(1):3-8. doi: 10.1016/j.pedneo.2019.11.009. Epub 2019 Nov 28.

Authors

Ping-Ing Lee¹, Yhu-Chering Huang², Kao-Pin Hwang³, Ching-Chuan Liu⁴, Cheng-Hsun Chiu², Po-Yen Chen⁵, Chun-Yi Lu⁶, Chih-Jung Chen², Luan-Yin Chang⁶, Nan-Chang Chiu⁷, Hsin Chi⁷, Hsiao-Chuan Lin³, Keh-Gong Wu⁸, Yu-Huai Ho⁹, Wu Sun¹⁰, Tzou-Yien Lin²

Affiliations

¹ Department of Pediatrics, National Taiwan University Children's Hospital, National Taiwan University Hospital and National Taiwan University College of Medicine, National Taiwan University, Taiwan. Electronic address: pinging@ntu.edu.tw.
² Division of Infectious Diseases, Department of Pediatrics, Chang Gung Children's Hospital, Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taiwan.
³ School of Medicine, China Medical University; Division of Pediatric Infectious Diseases, China Medical University Children's Hospital, Taiwan.
⁴ Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Taiwan.
⁵ Section of Pediatric Infectious Diseases, Department of Pediatrics, Taichung Veterans General Hospital, Taiwan.
⁶ Department of Pediatrics, National Taiwan University Children's Hospital, National Taiwan University Hospital and National Taiwan University College of Medicine, National Taiwan University, Taiwan.
⁷ Department of Pediatrics, MacKay Children's Hospital, Taiwan.
⁸ Department of Pediatrics, Taipei Veterans General Hospital and National Yang-Ming University, Taiwan.
⁹ Division of Infection Diseases, Department of Internal Medicine, Buddhist Tzu Chi General Hospital and Tzu Chi University, Taiwan.
¹⁰ Pao-Chien Hospital, Taiwan.

PMID: 31870559
DOI: 10.1016/j.pedneo.2019.11.009

Abstract

Japanese encephalitis (JE) is a mosquito-borne viral infection which is prevalent in Taiwan. The virus circulates in an enzootic cycle in pigs which serve as amplifying hosts. Outbreaks typically occur during summer. A universal vaccination program using 4-shot mouse brain-derived inactivated vaccine has successfully controlled JE epidemics in Taiwan since 1968. More than 90% of JE cases in recent years were older than 20 years in Taiwan. Because of several drawbacks, mouse brain-derived vaccine has been replaced by newer generation JE vaccines, including inactivated Vero cell-derived vaccine and live chimeric vaccine. The present article describes the recommendations in Taiwan for the use of new JE vaccines and the schedules for shifting between different JE vaccines.

Keywords: Japanese encephalitis; epidemiology; immunization schedule; vaccination.

Publication types

Review

MeSH terms

Encephalitis, Japanese / prevention & control*
Humans
Japanese Encephalitis Vaccines / immunology*
Taiwan
Vaccination*
Vaccines, Inactivated / immunology

Substances

Japanese Encephalitis Vaccines
Vaccines, Inactivated