Obesity is associated with shorter telomeres in 8 year-old children

Sci Rep. 2019 Dec 10;9(1):18739. doi: 10.1038/s41598-019-55283-8.

Abstract

Telomere length is considered a biomarker of biological aging. Shorter telomeres and obesity have both been associated with age-related diseases. To evaluate the association between various indices of obesity with leukocyte telomere length (LTL) in childhood, data from 1,396 mother-child pairs of the multi-centre European birth cohort study HELIX were used. Maternal pre-pregnancy body mass index (BMI) and 4 adiposity markers in children at age 8 (6-11) years were assessed: BMI, fat mass, waist circumference, and skinfold thickness. Relative LTL was obtained. Associations of LTL with each adiposity marker were calculated using linear mixed models with a random cohort effect. For each 1 kg/m² increment in maternal pre-pregnancy BMI, the child's LTL was 0.23% shorter (95%CI: 0.01,0.46%). Each unit increase in child BMI z-score was associated with 1.21% (95%CI: 0.30,2.11%) shorter LTL. Inverse associations were observed between waist circumference and LTL (-0.96% per z-score unit; 95%CI: -2.06,0.16%), and skinfold thickness and LTL (-0.10% per z-score unit; 95%CI: -0.23,0.02%). In conclusion, this large multicentric study suggests that higher child adiposity indicators are associated with short telomeres in children, and that associations are stronger for child BMI than for maternal pre-pregnancy BMI.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adiposity
  • Adult
  • Aging / genetics*
  • Aging / physiology
  • Biomarkers
  • Body Mass Index
  • Child
  • Cohort Studies
  • Female
  • Humans
  • Male
  • Obesity / genetics*
  • Pregnancy
  • Retrospective Studies
  • Risk Factors
  • Skinfold Thickness
  • Telomere / genetics*
  • Telomere / metabolism
  • Telomere Shortening / genetics
  • Telomere Shortening / physiology
  • Waist Circumference

Substances

  • Biomarkers