Impact of Candida auris Infection in a Neutropenic Murine Model

Antimicrob Agents Chemother. 2020 Feb 21;64(3):e01625-19. doi: 10.1128/AAC.01625-19. Print 2020 Feb 21.

Abstract

Candida auris has become a global public health threat due to its multidrug resistance and persistence. Currently, there are limited murine models to study C. auris infection. Those models use a combination of cyclophosphamide and cortisone acetate, suppressing both innate and adaptive immunity. Here, we compare C. auris infection in two neutrophil-depleted murine models in which innate immunity is targeted using the monoclonal antibodies 1A8 and RB6-8C5.

Keywords: Candida auris; Ly6C; Ly6G; microbiome; neutrophil depletion; torticollis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Monoclonal
  • Candida / drug effects
  • Candida / genetics
  • Candida / pathogenicity*
  • Candidiasis / drug therapy*
  • Candidiasis / immunology
  • Candidiasis / microbiology
  • Cortisone / therapeutic use*
  • Cyclophosphamide / therapeutic use*
  • Disease Models, Animal
  • Immunity, Innate / drug effects
  • Immunity, Innate / physiology
  • Mice
  • Neutrophils / metabolism

Substances

  • Antibodies, Monoclonal
  • Cyclophosphamide
  • Cortisone