Distinct Molecular Phenotype of Sporadic Colorectal Cancers Among Young Patients Based on Multiomics Analysis

Gastroenterology. 2020 Mar;158(4):1155-1158.e2. doi: 10.1053/j.gastro.2019.11.012. Epub 2019 Nov 13.
No abstract available

Keywords: Colorectal Cancer; Early-Onset; Sporadic; Young-Onset.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Age of Onset
  • Aged
  • Aged, 80 and over
  • Biomarkers, Tumor / analysis*
  • Chemokine CXCL12 / metabolism
  • Colorectal Neoplasms / blood
  • Colorectal Neoplasms / genetics*
  • Female
  • Gene Expression Profiling
  • Glutathione / metabolism
  • Humans
  • Intestinal Mucosa / metabolism
  • Male
  • Metabolomics
  • Microsatellite Repeats
  • Middle Aged
  • NF-E2-Related Factor 2 / metabolism
  • Oxidation-Reduction
  • Oxidative Stress / genetics
  • Phenotype
  • Prospective Studies
  • Proteomics
  • Receptors, CXCR4 / metabolism
  • Signal Transduction / genetics
  • Young Adult

Substances

  • Biomarkers, Tumor
  • CXCL12 protein, human
  • CXCR4 protein, human
  • Chemokine CXCL12
  • NF-E2-Related Factor 2
  • NFE2L2 protein, human
  • Receptors, CXCR4
  • Glutathione