The effects of long non-coding ribonucleic acids on various cellular components in rheumatoid arthritis

Yilong Fang; Jiajie Tu; Dafei Han; Yawei Guo; Wenming Hong; Wei Wei

doi:10.1093/rheumatology/kez472

The effects of long non-coding ribonucleic acids on various cellular components in rheumatoid arthritis

Rheumatology (Oxford). 2020 Jan 1;59(1):46-56. doi: 10.1093/rheumatology/kez472.

Authors

Yilong Fang^{1

2}, Jiajie Tu^{1

2}, Dafei Han^{1

2}, Yawei Guo^{1

2}, Wenming Hong^{1

2}, Wei Wei^{1

2}

Affiliations

¹ Institute of Clinical Pharmacology, Hefei, China.
² Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Anhui Medical University, Hefei, China.

Abstract

RA is a chronic, autoimmune-mediated inflammatory pathology. Long non-coding RNAs (lncRNAs) are a novel group of non-coding RNAs with a length of >200 nucleotides. There are reports emerging that suggest that lncRNAs participate in establishing and sustaining autoimmune diseases, including RA. In this review article, we highlight the functions of lncRNAs in different cell types in RA. Our review indicates that lncRNAs affect various cellular components and are novel candidates that could constitute promising targets for the diagnosis and treatment of RA.

Keywords: FLS; PBMCs; RA; T cells; lncRNA.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Arthritis, Rheumatoid / genetics*
Fibroblasts / metabolism*
Humans
Leukocytes, Mononuclear / metabolism*
RNA, Long Noncoding / physiology*
Synovial Fluid / cytology
T-Lymphocytes / metabolism*

Substances

RNA, Long Noncoding