Daily cooking duration and its joint effects with genetic polymorphisms on lung cancer incidence: Results from a Chinese prospective cohort study

Gege Wang; Yansen Bai; Wenshan Fu; Yue Feng; Weilin Chen; Guyanan Li; Xiulong Wu; Hua Meng; Yuhang Liu; Wei Wei; Suhan Wang; Sheng Wei; Xiaomin Zhang; Meian He; Handong Yang; Huan Guo

doi:10.1016/j.envres.2019.108747

Daily cooking duration and its joint effects with genetic polymorphisms on lung cancer incidence: Results from a Chinese prospective cohort study

Environ Res. 2019 Dec;179(Pt A):108747. doi: 10.1016/j.envres.2019.108747. Epub 2019 Sep 16.

Authors

Gege Wang¹, Yansen Bai¹, Wenshan Fu¹, Yue Feng¹, Weilin Chen¹, Guyanan Li¹, Xiulong Wu¹, Hua Meng¹, Yuhang Liu¹, Wei Wei¹, Suhan Wang¹, Sheng Wei², Xiaomin Zhang¹, Meian He¹, Handong Yang³, Huan Guo⁴

Affiliations

¹ Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
² Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
³ Dongfeng Central Hospital, Dongfeng Motor Corporation and Hubei University of Medicine, Shiyan, Hubei, China.
⁴ Department of Occupational and Environmental Health, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: ghuan5011@hust.edu.cn.

PMID: 31557604
DOI: 10.1016/j.envres.2019.108747

Abstract

Objectives: In this study, we conducted a prospective cohort study to investigate the joint effects of daily cooking duration with single nucleotide polymorphisms (SNPs) on lung cancer incidence.

Materials and methods: A total of 33,868 individuals recruited in 2013 from Dongfeng-Tongji cohort study were included in our research, in which 5178 participants were genotyped. Daily cooking duration was accessed by questionnaire, and the incident lung cancer cases were confirmed. Fifteen lung cancer related SNPs were selected according to the previous reports. We used the multiple Cox regression models to evaluate the separate and joint effects of daily cooking duration and SNPs on lung cancer incidence.

Results: Each 1-h increase in daily cooking duration was associated with a 17% elevated risk of lung cancer incidence [hazard ratio (HR) (95%CI) = 1.17(1.03, 1.33)]. Specifically, subjects with daily cooking duration >2 h/day had a 2.05-fold increased incident risk of lung cancer than those without cooking [HR(95%CI) = 2.05(1.20, 3.53)] (P_trend = 0.011). The rs2395185 and rs3817963, both located at 6p21.32, were significantly associated with lung cancer incidence. Compared with no cooking subjects with rs2395185GG or rs3817963TT genotype, subjects with daily cooking >2 h/day and carrying rs2395185GT + TT genotypes had a 2.48-fold increased risk of lung cancer [HR(95%CI) = 2.48(1.03, 5.97)], and there were significant joint effects of rs3817963TC + CC with daily cooking 1-2 and >2 h/day [HR(95%CI) = 2.23(1.07, 4.64) and 2.22(1.05, 4.68), respectively].

Conclusions: Longer daily cooking duration, especially daily cooking >2 h/day, was associated with increased risk of lung cancer. There were significant joint effects of rs2395185 and rs3817963 with daily cooking duration on lung cancer incidence. This study offered a new indicator of cooking related pollution exposure and added new evidence for the joint effects of environment and genetic factors on lung cancer incidence.

Keywords: Daily cooking duration; Indoor air pollution; Joint effect; Lung cancer; Single nucleotide polymorphism.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Asian People
Case-Control Studies
China
Cohort Studies
Cooking / statistics & numerical data*
Environmental Exposure / statistics & numerical data*
Humans
Incidence
Lung Neoplasms / epidemiology*
Lung Neoplasms / genetics
Polymorphism, Single Nucleotide
Prospective Studies
Risk Factors