Abstract
Nanomaterial-enabled chemiluminescence (CL) detection has become a growing area of interest in recent years. We review the development of nanomaterial-based CL detection strategies and their applications in bioanalysis. Much progress has been achieved in the past decade, but most attempts still remain in the proof-of-concept stage. This review highlights recent advances in nanomaterials in CL detection and organizes them into three groups based on their role in detection: as a sensing platform, as a signal probe, and applications in homogeneous systems. Furthermore, we have discussed the critical challenges we are facing and future prospects of this field.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Acridines / chemistry
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Adamantane / analogs & derivatives
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Adamantane / chemistry
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Biosensing Techniques
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Carbon / chemistry
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DNA, Catalytic / chemistry
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Gold / chemistry
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Humans
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Immunoassay
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Immunoglobulin G / chemistry
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Luminescence*
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Luminol / chemistry
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Metal Nanoparticles / chemistry
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Microscopy, Electron, Transmission
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Nanostructures / chemistry*
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Nanotechnology / methods*
Substances
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Acridines
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DNA, Catalytic
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Immunoglobulin G
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3-(2'-spiroadamantane)-4-methoxy-4-(3''-phosphoryloxy)phenyl-1,2-dioxetane
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10,10'-dimethyl-9,9'-biacridinium
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Luminol
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Carbon
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Gold
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Adamantane