A Nucleolar PARtnership Expands PARP Roles in RNA Biology and the Clinical Potential of PARP Inhibitors

Morgan Dasovich; Anthony K L Leung

doi:10.1016/j.molcel.2019.09.001

A Nucleolar PARtnership Expands PARP Roles in RNA Biology and the Clinical Potential of PARP Inhibitors

Mol Cell. 2019 Sep 19;75(6):1089-1091. doi: 10.1016/j.molcel.2019.09.001.

Authors

Morgan Dasovich¹, Anthony K L Leung²

Affiliations

¹ Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA; Department of Chemistry, Krieger School of Arts and Sciences, Johns Hopkins University, Baltimore, MD 21218, USA.
² Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA; Department of Molecular Biology and Genetics, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA; Department of Oncology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA. Electronic address: anthony.leung@jhu.edu.

PMID: 31539506
DOI: 10.1016/j.molcel.2019.09.001

Abstract

In this issue of Molecular Cell, Kim et al. (2019) identify small nucleolar RNAs (snoRNAs) as activators of poly(ADP-ribose) (PAR) synthesis, demonstrating that this snoRNA-PAR partnership promotes cancer cell growth independent of DNA repair pathways.

Publication types

Comment

MeSH terms

Poly (ADP-Ribose) Polymerase-1
Poly(ADP-ribose) Polymerase Inhibitors*
Poly(ADP-ribose) Polymerases
RNA Helicases
RNA, Small Nucleolar*
Ribosomes

Substances

Poly(ADP-ribose) Polymerase Inhibitors
RNA, Small Nucleolar
Poly (ADP-Ribose) Polymerase-1
Poly(ADP-ribose) Polymerases
RNA Helicases

Grants and funding

T32 GM080189/GM/NIGMS NIH HHS/United States