Antigenic Variation of Avian Influenza A(H5N6) Viruses, Guangdong Province, China, 2014-2018

Emerg Infect Dis. 2019 Oct;25(10):1932-1945. doi: 10.3201/eid2510.190274.

Abstract

Market surveillance showed continuing circulation of avian influenza A(H5N6) virus in live poultry markets in Guangdong Province in 2017, despite compulsory vaccination for avian influenza A(H5Nx) and A(H7N9). We analyzed H5N6 viruses from 2014-2018 from Guangdong Province, revealing antigenic drift and decreased antibody response against the vaccine strain in vaccinated chickens.

Keywords: Antigenic variation; China; Guangdong Province; H5N6; avian influenza; chickens; live poultry markets; poultry; viruses; zoonoses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, Viral / genetics*
  • Antigens, Viral / immunology
  • Chickens / virology
  • China / epidemiology
  • Genetic Drift
  • Influenza A virus / genetics
  • Influenza A virus / immunology*
  • Influenza in Birds / epidemiology
  • Influenza in Birds / genetics
  • Influenza in Birds / immunology*
  • Influenza in Birds / virology
  • Phylogeny
  • Poultry Diseases / epidemiology
  • Poultry Diseases / immunology
  • Poultry Diseases / virology*
  • Real-Time Polymerase Chain Reaction / veterinary
  • Reverse Transcriptase Polymerase Chain Reaction / veterinary

Substances

  • Antigens, Viral