Role of intrinsic disorder in muscle sarcomeres

Prog Mol Biol Transl Sci. 2019:166:311-340. doi: 10.1016/bs.pmbts.2019.03.014. Epub 2019 Apr 13.

Abstract

The role and utility of intrinsically disordered regions (IDRs) is reviewed for two groups of sarcomeric proteins, such as members of tropomodulin/leiomodin (Tmod/Lmod) protein homology group and myosin binding protein C (MyBP-C). These two types of sarcomeric proteins represent very different but strongly interdependent functions, being responsible for maintaining structure and operation of the muscle sarcomere. The role of IDRs in the formation of complexes between thin filaments and Tmods/Lmods is discussed within the framework of current understanding of the thin filament length regulation. For MyBP-C, the function of IDRs is discussed in the context of MYBP-C-dependent sarcomere contraction and actomyosin activation.

Keywords: Actin; Intrinsically disordered region; Leiomodin; Myosin; Myosin binding protein C; Sarcomere; Thick filament; Thin filament; Tropomodulin; Tropomyosin.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Binding Sites
  • Carrier Proteins / metabolism
  • Humans
  • Intrinsically Disordered Proteins / chemistry
  • Intrinsically Disordered Proteins / metabolism*
  • Muscles / metabolism*
  • Sarcomeres / metabolism*
  • Tropomodulin / chemistry
  • Tropomodulin / metabolism*

Substances

  • Carrier Proteins
  • Intrinsically Disordered Proteins
  • Tropomodulin
  • myosin-binding protein C